Mechanism of Action of Metronidazole Metronidazole is nitro imidazoles which have broad spectrum cidal activity against Protozoa and some anaerobic bacteria Its selective toxicity to anaerobic microbes involves 1 Drug enters the cell by diffusion, 2Studies in dogs suggest, however, that spiramycin has no effect on gut motility (Qin et al, 1987;Mechanism of action Macrolides act at the ribosomal level, specifically on the 50S subunit, blocking its action By doing this, they inhibit the protein synthesis of sensitive microorganisms without affecting the ribosomes of mammals This effect manages to prevent the growth of bacteria Due to their mechanism of action, macrolides are
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